Microglia P2Y13 Receptors Prevent Astrocyte Proliferation Mediated by P2Y1 Receptors.

ABSTRACT: Cerebral inflammation is a common feature of several neurodegenerative diseases that requires a fine interplay between astrocytes and microglia to acquire appropriate phenotypes for an efficient response to neuronal damage. During brain inflammation, ATP is massively released into the extracellular medium and converted into ADP. Both nucleotides acting on P2 receptors, modulate astrogliosis through mechanisms involving microglia-astrocytes communication. In previous studies, primary cultures of astrocytes and co-cultures of astrocytes and microglia were used to investigate the influence of microglia on astroglial proliferation induced by ADPβS, a stable ADP analog. In astrocyte cultures, ADPβS increased cell proliferation through activation of P2Y1 and P2Y12 receptors, an effect abolished

SUBMITTER: Quintas C 

PROVIDER: S-EPMC5943495 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature