WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer.

ABSTRACT:

Background

Metastatic spread is responsible for the majority of cancer-associated deaths. The tumour microenvironment, including hypoxia, is a major driver of metastasis. The aim of this study was to investigate the role of the E3 ligase WSB-1 in breast cancer biology in the context of the hypoxic tumour microenvironment, particularly regarding metastatic spread.

Methods

In this study, WSB-1 expression was evaluated in breast cancer cell lines and patient samples. In silico analyses were used to determine the impact of WSB-1 expression on distant metastasis-free survival (DMFS) in patients, and correlation between WSB1 expression and hypoxia gene expression signatures. The role of WSB-1 on metastasis promotion was evaluated in vitro and in vivo.

Results

High WSB1 expr

SUBMITTER: Poujade FA 

PROVIDER: S-EPMC5943535 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature