Association of Minimal Residual Disease With Superior Survival Outcomes in Patients With Multiple Myeloma: A Meta-analysis.

ABSTRACT:

Importance

Numerous studies have evaluated the prognostic value of minimal residual disease (MRD) in patients with multiple myeloma (MM). Most studies were small and varied in terms of patient population, treatment, and MRD assessment methods.

Objective

To evaluate the utility of MRD detection in patients with newly diagnosed MM.

Data sources

A Medline search was conducted for articles published in English between January 1990 and January 2016.

Study selection

Eligible studies reported MRD status and progression-free survival (PFS) or overall survival (OS) in 20 or more patients following treatment. Among 405 articles identified, 21 met the initial eligibility criteria and were included in the analysis.

Data extraction and synthesis

Information on patien

SUBMITTER: Munshi NC 

PROVIDER: S-EPMC5943640 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature