Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to <i>Mycobacterium tuberculosis</i> Infection.

ABSTRACT: Iron is an essential factor for the growth and virulence of Mycobacterium tuberculosis (Mtb). However, little is known about the mechanisms by which the host controls iron availability during infection. Since ferritin heavy chain (FtH) is a major intracellular source of reserve iron in the host, we hypothesized that the lack of FtH would cause dysregulated iron homeostasis to exacerbate TB disease. Therefore, we used knockout mice lacking FtH in myeloid-derived cell populations to study Mtb disease progression. We found that FtH plays a critical role in protecting mice against Mtb, as evidenced by increased organ burden, extrapulmonary dissemination, and decreased survival in Fth^-/- mice. Flow cytometry analysis showed that reduced levels of Ft

SUBMITTER: Reddy VP 

PROVIDER: S-EPMC5943674 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature