The importance of hippocampal dynamic connectivity in explaining memory function in multiple sclerosis.

ABSTRACT:

Introduction

Brain dynamics (i.e., variable strength of communication between areas), even at the scale of seconds, are thought to underlie complex human behavior, such as learning and memory. In multiple sclerosis (MS), memory problems occur often and have so far only been related to "stationary" brain measures (e.g., atrophy, lesions, activation and stationary (s) functional connectivity (FC) over an entire functional scanning session). However, dynamics in FC (dFC) between the hippocampus and the (neo)cortex may be another important neurobiological substrate of memory impairment in MS that has not yet been explored. Therefore, we investigated hippocampal dFC during a functional (f) magnetic resonance imaging (MRI) episodic memory task and its relationship with verbal and visuosp

SUBMITTER: van Geest Q 

PROVIDER: S-EPMC5943730 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature