Prognostic significance of anaemia in patients with heart failure with preserved and reduced ejection fraction: results from the MAGGIC individual patient data meta-analysis.

ABSTRACT:

Background

Anaemia is common among patients with heart failure (HF) and is an important prognostic marker.

Aim

We sought to determine the prognostic importance of anaemia in a large multinational pooled dataset of prospectively enrolled HF patients, with the specific aim to determine the prognostic role of anaemia in HF with preserved and reduced ejection fraction (HF-PEF and HF-REF, respectively).

Design

Individual person data meta-analysis.

Methods

Patients with haemoglobin (Hb) data from the MAGGIC dataset were used. Anaemia was defined as Hb < 120 g/l in women and <130 g/l in men. HF-PEF was defined as EF ≥ 50%; HF-REF was EF < 50%. Cox proportional hazard modelling, with adjustment for clinically relevant variables, was undertaken to investigate factors as

SUBMITTER: Berry C 

PROVIDER: S-EPMC5943826 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature