Association between IGF-1 polymorphisms and risk of osteoporosis in Chinese population: a meta-analysis.

ABSTRACT:

Background

Several studies looking into the association between insulin-like growth factor-1 (IGF-1) gene polymorphisms and osteoporosis predisposition have been conducted among Chinese population with conflicting outcomes. The present systematic review and meta-analysis was performed to appraise and synthesize the existing evidence, so as to provide a more precise and reliable association between polymorphisms in IGF-1 gene and osteoporosis.

Methods

Five electronic databases including PubMed, EMBASE, ISI Web of Science, CNKI and Wanfang were systematically searched for potential studies. Summary odds ratio (OR) and corresponding 95% confidence interval (95% CI) were calculated to evaluate the association. The best-matching genetic model of inheritance was determined using a

SUBMITTER: Gao ST 

PROVIDER: S-EPMC5944070 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature