Roxithromycin monotherapy inducing a partial response in a patient with myeloma: a case report.

ABSTRACT:

Background

Clarithromycin is an efficacious treatment for myeloma in combination with other anti-myeloma therapy but not as monotherapy. To date, all studies have focused on a clarithromycin-specific effect rather than a class effect (macrolide) and there is no information on the activity of roxithromycin in myeloma.

Case presentation

Here we report an untreated 86-year-old New Zealand European white man with IgA myeloma whose paraprotein decreased by 57%, consistent with a partial response, after a course of roxithromycin for pneumonia. His paraprotein reduced from 46 to 20 g/L while his hemoglobin improved from 97 to 123 g/L after 1 month.

Conclusion

Additional investigations should be considered to elucidate the therapeutic effect of roxithromycin in myeloma.

SUBMITTER: Chai KY 

PROVIDER: S-EPMC5944102 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature