ICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells.

ABSTRACT:

Objective

Regulation of intercellular adhesion molecule (ICAM)-1 in retinal endothelial cells is a promising druggable target for retinal vascular diseases. The ICAM-1-related (ICR) long non-coding RNA stabilizes ICAM-1 transcript, increasing protein expression. However, studies of ICR involvement in disease have been limited as the promoter is uncharacterized. To address this issue, we undertook a comprehensive in silico analysis of the human ICR gene promoter region.

Results

We used genomic evolutionary rate profiling to identify a 115 base pair (bp) sequence within 500 bp upstream of the transcription start site of the annotated human ICR gene that was conserved across 25 eutherian genomes. A second constrained sequence upstream of the orthologous mouse gene (68 bp; conse

SUBMITTER: Lumsden AL 

PROVIDER: S-EPMC5944171 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature