Thallium Labeled Citrate-Coated Prussian Blue Nanoparticles as Potential Imaging Agent.

ABSTRACT:

Background

The aim of this study was to develop and characterize a nanoparticle-based image-contrast platform which is biocompatible, chemically stable, and accessible for radiolabeling with ²⁰¹Tl. We explored whether this nanoparticle enhanced the T1 signal which might make it an MRI contrast agent as well.

Methods

The physical properties of citrate-coated Prussian blue nanoparticles (PBNPs) (iron(II);iron(III);octadecacyanide) doped with ²⁰¹Tl isotope were characterized with atomic force microscopy, dynamic light scattering, and zeta potential measurement. PBNP biodistribution was determined by using SPECT and MRI following intravenous administration into C57BL6 mice. Activity concentrations (MBq/cm³) were calculated from the SPECT scans fo

SUBMITTER: Szigeti K 

PROVIDER: S-EPMC5944205 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature