Prevalence of Orofacial Clefts among Live Births in China: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Orofacial clefts (OFCs) are common human birth defects in China. However, studies on the prevalence of OFCs present inconsistent results. The overall prevalence and geographic distribution of OFCs are poorly described in China. Thus, we conducted a systematic review and meta-analysis to estimate the prevalence of OFCs.

Methods

The systematic review and meta-analysis were conducted on the basis of an established protocol (PROSPERO 2015: CRD42015030198). We systematically searched for articles in four electronic databases, including Embase, PubMed, Wanfang Database, and China National Knowledge Infrastructure (CNKI) to identify relevant studies about prevalence of OFCs in China. Meta-analysis, including subgroup analysis, was conducted to estimate the pooled prevale

SUBMITTER: Wang M 

PROVIDER: S-EPMC5944334 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature