Dynamic Functional Connectivity States Reflecting Psychotic-like Experiences.

ABSTRACT:

Background

Psychotic-like experiences (PLEs) are associated with lower social and occupational functioning, and lower executive function. Emerging evidence also suggests that PLEs reflect neural dysfunction resembling that of psychotic disorders.

Methods

The present study examined dynamic connectivity related to a measure of PLEs derived from the Achenbach Adult Self-Report, in an otherwise-healthy sample of adults from the Human Connectome Project. A total of 76 PLE-endorsing and 153 control participants were included in the final sample. To characterize network dysfunction, dynamic connectivity states were examined across large-scale resting-state networks using dynamic conditional correlation and k-means clustering.

Results

Three dynamic states were identified. The

SUBMITTER: Barber AD 

PROVIDER: S-EPMC5944620 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature