Differential T cell response against BK virus regulatory and structural antigens: A viral dynamics modelling approach.

ABSTRACT: BK virus (BKV) associated nephropathy affects 1-10% of kidney transplant recipients, leading to graft failure in about 50% of cases. Immune responses against different BKV antigens have been shown to have a prognostic value for disease development. Data currently suggest that the structural antigens and regulatory antigens of BKV might each trigger a different mode of action of the immune response. To study the influence of different modes of action of the cellular immune response on BKV clearance dynamics, we have analysed the kinetics of BKV plasma load and anti-BKV T cell response (Elispot) in six patients with BKV associated nephropathy using ODE modelling. The results show that only a small number of hypotheses on the mode of action are compatible with the empirical data. The hypothes

SUBMITTER: Blazquez-Navarro A 

PROVIDER: S-EPMC5944912 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature