Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs.

ABSTRACT: Knowledge on the genetic epidemiology of disorders in the dog population has implications for both veterinary medicine and sustainable breeding. Limited data on frequencies of genetic disease variants across breeds exists, and the disease heritage of mixed breed dogs remains poorly explored to date. Advances in genetic screening technologies now enable comprehensive investigations of the canine disease heritage, and generate health-related big data that can be turned into action. We pursued population screening of genetic variants implicated in Mendelian disorders in the largest canine study sample examined to date by examining over 83,000 mixed breed and 18,000 purebred dogs representing 330 breeds for 152 known variants using a custom-designed beadchip microarray. We further announce the

SUBMITTER: Donner J 

PROVIDER: S-EPMC5945203 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature