Metabolite profiling for biomarkers in Schistosoma haematobium infection and associated bladder pathologies.

ABSTRACT:

Background

Metabolic fingerprinting analysis can offer insights into underlying reactions in a biological system; hence it is crucial to the understanding of disease pathogenesis and could provide useful tools for discovering biomarkers. We sought to examine the urine and plasma metabolome in individuals affected by urogenital schistosomiasis and its associated-bladder pathologies.

Methodology

Blood and midstream urine were obtained from volunteers who matched our inclusion criteria among residents from Eggua, southwestern Nigeria. Samples were screened by urinalysis, microscopy, PCR and ultrasonography, and categorised as advanced (urogenital schistosomiasis associated-bladder pathologies), infection-only (urogenital schistosomiasis alone) and controls (no infection and no

SUBMITTER: Adebayo AS 

PROVIDER: S-EPMC5945272 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature