In-utero exposure to antiretrovirals and neurodevelopment among HIV-exposed-uninfected children in Botswana.

ABSTRACT:

Objective

Conflicting data exist regarding the impact of in-utero exposure to maternal combination antiretrovirals. We compared neurodevelopmental outcomes between HIV-exposed-uninfected (HEU) children exposed in utero to three-drug combination antiretroviral therapy (ART) vs. zidovudine (ZDV) monotherapy.

Design

Prospective study of child neurodevelopment, nested within two cohorts of HIV-infected mothers and their children in Botswana (one observational, one interventional).

Methods

The Tshipidi and Mma Bana studies enrolled HIV-infected women during pregnancy and followed their HEU children for 24 months. Mothers took three-drug ART or ZDV during pregnancy. ART-exposed babies were mostly breastfed, and ZDV-exposed were formula-fed. Neurodevelopmental outcomes, meas

SUBMITTER: Chaudhury S 

PROVIDER: S-EPMC5945299 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature