Prolonged in vivo functional assessment of the mouse oviduct using optical coherence tomography through a dorsal imaging window.

ABSTRACT: The oviduct (or fallopian tube) serves as an environment for gamete transport, fertilization and preimplantation embryo development in mammals. Although there has been increasing evidence linking infertility with disrupted oviduct function, the specific roles that the oviduct plays in both normal and impaired reproductive processes remain unclear. The mouse is an important mammalian model to study human reproduction. However, most of the current analyses of the mouse oviduct rely on static histology or 2D visualization, and are unable to provide dynamic and volumetric characterization of this organ. The lack of imaging access prevents longitudinal live analysis of the oviduct and its associated reproductive events, limiting the understanding of mechanistic aspects of fertilization and prei

SUBMITTER: Wang S 

PROVIDER: S-EPMC5945336 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature