Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial.

ABSTRACT:

Background

The high levels of eicosanoid production and the clinical efficacy of leukotriene-modifying pharmacotherapies for patients with aspirin-exacerbated respiratory disease (AERD) suggest that other interventions targeting arachidonic acid dysregulation may also improve disease control.

Objective

To assess the utility of a high omega-3/low omega-6 diet for the treatment of AERD.

Methods

Prospective, nonblinded dietary intervention in 10 adult patients with AERD at Brigham and Women's Hospital in Boston, MA. The primary objective was for subjects to reduce dietary omega-6 fatty acid consumption to less than 4 g/d and increase omega-3 intake to more than 3 g/d. The primary outcome was change in urinary leukotriene E₄, with changes in other eicosanoids,

SUBMITTER: Schneider TR 

PROVIDER: S-EPMC5945343 | biostudies-literature | 2018 May - Jun

REPOSITORIES: biostudies-literature