Pushing the Limits: Machine Preservation of the Liver as a Tool to Recondition High-Risk Grafts.

ABSTRACT:

Purpose of the review

Machine perfusion (MP) is a novel technology recently introduced in liver transplantation, redefining the current practice of organ preservation and pushing the limits of high-risk liver utilisation. This review highlights the key benefits of machine perfusion over conventional static cold storage (SCS), demonstrated in human liver research and clinical transplants.

Recent findings

The first clinical trials have demonstrated both safety and feasibility of MP. The most recent transplant series and result from a randomised trial suggest the technology is superior to SCS. The key benefits include extended period of organ preservation, decreased incidence of early allograft dysfunction and reduction of biliary complications. Normothermic liver perfusion all

SUBMITTER: Boteon YL 

PROVIDER: S-EPMC5945712 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature