3D confocal laser-scanning microscopy for large-area imaging of the corneal subbasal nerve plexus.

ABSTRACT: The capability of corneal confocal microscopy (CCM) to acquire high-resolution in vivo images of the densely innervated human cornea has gained considerable interest in using this non-invasive technique as an objective diagnostic tool for staging peripheral neuropathies. Morphological alterations of the corneal subbasal nerve plexus (SNP) assessed by CCM have been shown to correlate well with the progression of neuropathic diseases and even predict future-incident neuropathy. Since the field of view of single CCM images is insufficient for reliable characterisation of nerve morphology, several image mosaicking techniques have been developed to facilitate the assessment of the SNP in large-area visualisations. Due to the limited depth of field of confocal microscopy, these approaches are hi

SUBMITTER: Allgeier S 

PROVIDER: S-EPMC5945773 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature