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Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis.

ABSTRACT: Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement of the DN in Hb kidney injury was suggested by the induction of renal hepcidin synthesis (p?

SUBMITTER: van Swelm RPL 

PROVIDER: S-EPMC5945780 | biostudies-literature |

REPOSITORIES: biostudies-literature

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