Spontaneous Hair Cell Regeneration Is Prevented by Increased Notch Signaling in Supporting Cells.

ABSTRACT: During embryonic development, differentiation of cochlear progenitor cells into hair cells (HCs) or supporting cells (SCs) is partially controlled through Notch signaling. Many studies have shown that inhibition of Notch signaling allows SCs to convert into HCs in both normal and drug damaged neonatal mouse cochleae. This mechanism is also implicated during HC regeneration in non-mammalian vertebrates; however, the mechanism of spontaneous HC regeneration in the neonatal mouse cochlea is less understood. While inhibition of Notch signaling can force SCs to convert into HCs and increase the number of regenerated HCs, it is currently unknown whether this pathway is involved in spontaneous HC regeneration observed in vivo. Therefore, we investigated the role of Notch signaling during t

SUBMITTER: McGovern MM 

PROVIDER: S-EPMC5945818 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature