Genomic analysis identifies masqueraders of full-term cerebral palsy.

ABSTRACT:

Objective

Cerebral palsy is a common, heterogeneous neurodevelopmental disorder that causes movement and postural disabilities. Recent studies have suggested genetic diseases can be misdiagnosed as cerebral palsy. We hypothesized that two simple criteria, that is, full-term births and nonspecific brain MRI findings, are keys to extracting masqueraders among cerebral palsy cases due to the following: (1) preterm infants are susceptible to multiple environmental factors and therefore demonstrate an increased risk of cerebral palsy and (2) brain MRI assessment is essential for excluding environmental causes and other particular disorders.

Methods

A total of 107 patients-all full-term births-without specific findings on brain MRI were identified among 897 patients diagnosed with

SUBMITTER: Takezawa Y 

PROVIDER: S-EPMC5945967 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature