Progranulin levels in blood in Alzheimer's disease and mild cognitive impairment.

ABSTRACT:

Objective

Changes in progranulin (GRN) expression have been hypothesized to alter risk for Alzheimer's disease (AD). We investigated the relationship between GRN expression in peripheral blood and clinical diagnosis of AD and mild cognitive impairment (MCI).

Methods

Peripheral blood progranulin gene expression was measured, using microarrays from Alzheimer's (n = 186), MCI (n = 118), and control (n = 204) subjects from the University of California San Francisco Memory and Aging Center (UCSF-MAC) and two independent published series (AddNeuroMed and ADNI). GRN gene expression was correlated with clinical, demographic, and genetic data, including APOE haplotype and the GRN rs5848 single-nucleotide polymorphism. Finally, we asses

SUBMITTER: Cooper YA 

PROVIDER: S-EPMC5945969 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature