Dataset Information

Deep Surveying of the Transcriptional and Alternative Splicing Signatures for Decidual CD8⁺ T Cells at the First Trimester of Human Healthy Pregnancy.

ABSTRACT: Decidual CD8⁺ (dCD8) T cells have been proposed to play important roles in immune protection against the invading pathogens and in tolerance toward the growing semi-allogeneic fetus during early pregnancy. However, their phenotypic and functional characteristics remain poorly defined. Here, we performed the first analysis of the transcriptional and alternative splicing (AS) signatures for human first-trimester dCD8 T cells using high-throughput mRNA sequencing. Our data revealed that dCD8 T cells have distinct transcriptional and AS landscapes when compared with their autologous peripheral blood CD8⁺ (pCD8) T counterparts. Furthermore, human dCD8 T cells were observed to contain CD8-Treg and effector-memory T-cell subsets, and display enhanced functionality in terms o

SUBMITTER: Zeng W

PROVIDER: S-EPMC5946033 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Dataset Information

Deep Surveying of the Transcriptional and Alternative Splicing Signatures for Decidual CD8⁺ T Cells at the First Trimester of Human Healthy Pregnancy.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Deep Surveying of the Transcriptional and Alternative Splicing Signatures for Decidual CD8+ T Cells at the First Trimester of Human Healthy Pregnancy.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Deep Surveying of the Transcriptional and Alternative Splicing Signatures for Decidual CD8⁺ T Cells at the First Trimester of Human Healthy Pregnancy.