Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction.

ABSTRACT: Aging is characterized by numerous molecular changes, such as accumulation of molecular damage and altered gene expression, many of which are linked to DNA methylation. Here, we characterize the blood DNA methylome across 16 age groups of mice and report numerous global, region- and site-specific features, as well as the associated dynamics of methylation changes. Transition of the methylome throughout lifespan was not uniform, with many sites showing accelerated changes in late life. The associated genes and promoters were enriched for aging-related pathways, pointing to a fundamental link between DNA methylation and control of the aging process. Calorie restriction both shifted the overall methylation pattern and was accompanied by its gradual age-related remodeling, the latter contribut

SUBMITTER: Sziraki A 

PROVIDER: S-EPMC5946071 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature