Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability.

ABSTRACT: Gene expression is dynamically regulated in a variety of mammalian physiologies. During mammalian aging, there are changes that occur in protein expression that are highly controlled by the regulatory steps in transcription, post-transcription, and post-translation. Although there are global profiles of human transcripts during the aging processes available, the mechanism(s) by which transcripts are differentially expressed between young and old cohorts remains unclear. Here, we report on N6-methyladenosine (m6A) RNA modification profiles of human peripheral blood mononuclear cells (PBMCs) from young and old cohorts. An m6A RNA profile identified a decrease in overall RNA methylation during the aging process as well as the predominant modification on proteincoding mRNAs. The m6A-modified t

SUBMITTER: Min KW 

PROVIDER: S-EPMC5946072 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature