Hyperglycaemia is inversely correlated with live M. bovis BCG-specific CD4⁺ T cell responses in Tanzanian adults with latent or active tuberculosis.

ABSTRACT:

Introduction

The rising prevalence of Diabetes mellitus (DM) in high TB-endemic countries may adversely affect sustainability of TB control since DM constitutes a risk factor for development of active tuberculosis (TB). The impact of DM on TB specific adaptive immune responses remains poorly addressed, particularly in people living in Sub-Saharan countries. We performed a functional characterization of TB specific cellular immune response in Tanzanian subjects with active or latent Mycobacterium tuberculosis (Mtb) infection stratified by their diabetic status.

Methods

HIV negative active TB patients (≥18 years) with Xpert MTB/RIF positive pulmonary TB were included before starting TB treatment in Dar es Salaam, Tanzania between April and December 2013. HIV negative healthy c

SUBMITTER: Boillat-Blanco N 

PROVIDER: S-EPMC5946156 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature