Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection.

ABSTRACT:

Introduction

Zika virus (ZIKV) and dengue virus (DENV) co-circulated during latest outbreaks in Brazil, hence, it is important to evaluate the host cross-reactive immune responses to these viruses. So far, little is known about human T cell responses to ZIKV and no reports detail adaptive immune responses during DENV/ZIKV coinfection.

Methods

Here, we studied T cells responses in well-characterized groups of DENV, ZIKV, or DENV/ZIKV infected patients and DENV-exposed healthy donors. We evaluated chemokine receptors expression and single/multifunctional frequencies of IFNγ, TNF, and IL2-producing T cells during these infections. Even without antigenic stimulation, it was possible to detect chemokine receptors and IFNγ, TNF, and IL2-producing T cells from all individuals by fl

SUBMITTER: Badolato-Correa J 

PROVIDER: S-EPMC5946158 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature