Associations of coronary artery calcified plaque density with mortality in type 2 diabetes: the Diabetes Heart Study.

ABSTRACT:

Background

Coronary artery calcified plaque (CAC) is strongly predictive of cardiovascular disease (CVD) events and mortality, both in general populations and individuals with type 2 diabetes at high risk for CVD. CAC is typically reported as an Agatston score, which is weighted for increased plaque density. However, the role of CAC density in CVD risk prediction, independently and with CAC volume, remains unclear.

Methods

We examined the role of CAC density in individuals with type 2 diabetes from the family-based Diabetes Heart Study and the African American-Diabetes Heart Study. CAC density was calculated as mass divided by volume, and associations with incident all-cause and CVD mortality [median follow-up 10.2 years European Americans (n = 902, n = 286 deceased), 5.2 ye

SUBMITTER: Raffield LM 

PROVIDER: S-EPMC5946410 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature