Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion.

ABSTRACT:

Background

Aspergillus fumigatus has to cope with a combination of several stress types while colonizing the human body. A functional interplay between these different stress responses can increase the chances of survival for this opportunistic human pathogen during the invasion of its host. In this study, we shed light on how the H₂O₂-induced oxidative stress response depends on the iron available to this filamentous fungus, using transcriptomic analysis, proteomic profiles, and growth assays.

Results

The applied H₂O₂ treatment, which induced only a negligible stress response in iron-replete cultures, deleteriously affected the fungus under iron deprivation. The majority of stress-induced changes in gene and protein expression was

SUBMITTER: Kurucz V 

PROVIDER: S-EPMC5946477 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature