Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses.

ABSTRACT: Recently, electron transfers and catalyses in a bevy of redox reactions mediated by hemeproteins were explained by murburn concept. The term "murburn" is abstracted from "muredburning" or "mildunrestrictedburning" and connotes a novel "molecule-unbound ion-radical" interaction paradigm. Quite unlike the genetic regulations and protein-level affinity-based controls that govern order and specificity/selectivity in conventional treatments, murburn concept is based on stochastic/thermodynamic regulatory principles. The novel insight necessitates a "reactivity outside the active-site" perspective, because select redox enzymatic activity is obligatorily mediated via diffu

SUBMITTER: Parashar A 

PROVIDER: S-EPMC5946624 | biostudies-literature | 2018 Apr-Jun

REPOSITORIES: biostudies-literature