Parvalbumin and GABA Microcircuits in the Mouse Superior Colliculus.

ABSTRACT: The mammalian superior colliculus (SC) is a sensorimotor midbrain structure responsible for orienting behaviors. Although many SC features are known, details of its intrinsic microcircuits are lacking. We used transgenic mice expressing reporter genes in parvalbumin-positive (PV⁺) and gamma aminobutyric acid-positive (GABA⁺) neurons to test the hypothesis that PV⁺ neurons co-localize GABA and form inhibitory circuits within the SC. We found more PV⁺ neurons in the superficial compared to the intermediate SC, although a larger percentage of PV⁺ neurons co-expressed GABA in the latter. Unlike PV⁺ neurons, PV⁺/GABA⁺ neurons showed predominantly rapidly inactivating spiking patterns. Optogenetic activation

SUBMITTER: Villalobos CA 

PROVIDER: S-EPMC5946669 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature