Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes.

ABSTRACT: The liver and the mononuclear phagocyte system are a frequent target for engineered nanomaterials, either as a result of particle uptake and spread from primary exposure sites or systemic administration of therapeutic and imaging nanoparticles. In this study, we performed a comparative analysis of the toxicological impact of 29 metal oxide nanoparticles (NPs), some commonly used in consumer products, in transformed or primary Kupffer cells (KCs) and hepatocytes. We not only observed differences between KCs and hepatocytes, but also differences in the toxicological profiles of transition-metal oxides (TMOs, e. g., Co₃O₄) versus rare-earth oxide (REO) NPs ( e. g., Gd₂O₃). While pro-oxidative TMOs induced the activation of caspases 3 and 7, resultin

SUBMITTER: Mirshafiee V 

PROVIDER: S-EPMC5946698 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature