Rapid Neuromodulation of Layer 1 Interneurons in Human Neocortex.

ABSTRACT: Inhibitory interneurons govern virtually all computations in neocortical circuits and are in turn controlled by neuromodulation. While a detailed understanding of the distinct marker expression, physiology, and neuromodulator responses of different interneuron types exists for rodents and recent studies have highlighted the role of specific interneurons in converting rapid neuromodulatory signals into altered sensory processing during locomotion, attention, and associative learning, it remains little understood whether similar mechanisms exist in human neocortex. Here, we use whole-cell recordings combined with agonist application, transgenic mouse lines, in situ hybridization, and unbiased clustering to directly determine these features in human layer 1 interneurons (L1-INs). Our results

SUBMITTER: Poorthuis RB 

PROVIDER: S-EPMC5946807 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature