Noninfectious Manifestations and Complications of Chronic Granulomatous Disease.

ABSTRACT: Chronic granulomatous disease (CGD), a primary immunodeficiency characterized by a deficient neutrophil oxidative burst and the inadequate killing of microbes, is well known to cause a significantly increased risk of invasive infection. However, infectious complications are not the sole manifestations of CGD; substantial additional morbidity is driven by noninfectious complications also. These complications can include, for example, a wide range of inflammatory diseases that affect the gastrointestinal tract, lung, skin, and genitourinary tract and overt autoimmune disease. These diseases can occur at any age and are especially problematic in adolescents and adults with CGD. Many of these noninfectious complications present a highly challenging therapeutic conundrum, wherein immunosuppress

SUBMITTER: Henrickson SE 

PROVIDER: S-EPMC5946858 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature