Altered diurnal states in insomnia reflect peripheral hyperarousal and metabolic desynchrony: a preliminary study.

ABSTRACT:

Study objectives

Insomnia is a common sleep disorder that is associated with a range of adverse outcomes. Patients with insomnia exhibit hyperarousal in multiple domains, including an elevated metabolic rate, but specific metabolic molecular perturbations are unknown. Furthermore, objective clinical markers of insomnia are not available and current assessment of pathological extent relies on self-report. Here, we provide preliminary evidence that chronic insomnia is remarkably reflected in the periphery through detailed metabolic assessments.

Methods

Serum from confirmed patients with insomnia and matched good sleepers (n = 15 per group) was sampled at high temporal resolution (every 2 hr over 48 hr). Food intake was controlled by providing hourly isocaloric snacks, and slee

SUBMITTER: Gehrman P 

PROVIDER: S-EPMC5946940 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature