Plasma proteomic analysis of systemic lupus erythematosus patients using liquid chromatography/tandem mass spectrometry with label-free quantification.

ABSTRACT:

Context

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with unknown etiology.

Objective

Human plasma is comprised of over 10 orders of magnitude concentration of proteins and tissue leakages. The changes in the abundance of these proteins have played an important role in various human diseases. Therefore, the research objective of this study is to identify the significantly altered expression levels of plasma proteins from SLE patients compared with healthy controls using proteomic analysis. The plasma proteome profiles of both SLE patients and controls were compared.

Methods

A total of 19 active SLE patients and 12 healthy controls plasma samples were analyzed using high-resolution electrospray ionization liquid chromatography-tandem

SUBMITTER: Madda R 

PROVIDER: S-EPMC5947061 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature