Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells.

ABSTRACT: The entorhinal cortex is a crucial component of our memory and spatial navigation systems and is one of the first areas to be affected in dementias featuring tau pathology, such as Alzheimer's disease and frontotemporal dementia. Electrophysiological recordings from principle cells of medial entorhinal cortex (layer II stellate cells, mEC-SCs) demonstrate a number of key identifying properties including subthreshold oscillations in the theta (4-12 Hz) range and clustered action potential firing. These single cell properties are correlated with network activity such as grid firing and coupling between theta and gamma rhythms, suggesting they are important for spatial memory. As such, experimental models of dementia have revealed disruption of organised dorsoventral gradients in clustered ac

SUBMITTER: Tait L 

PROVIDER: S-EPMC5947116 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature