Morning surge in blood pressure using a random-effects multiple-component cosinor model.

ABSTRACT: Blood pressure (BP) fluctuates throughout the day. The pattern it follows represents one of the most important circadian rhythms in the human body. For example, morning BP surge has been suggested as a potential risk factor for cardiovascular events occurring in the morning, but the accurate quantification of this phenomenon remains a challenge. Here, we outline a novel method to quantify morning surge. We demonstrate how the most commonly used method to model 24-hour BP, the single cosinor approach, can be extended to a multiple-component cosinor random-effects model. We outline how this model can be used to obtain a measure of morning BP surge by obtaining derivatives of the model fit. The model is compared with a functional principal component analysis that determines the main component

SUBMITTER: Madden JM 

PROVIDER: S-EPMC5947147 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature