Spectroscopic Studies on Photoinduced Reactions of the Anticancer Prodrug, trans,trans,trans-[Pt(N₃ )₂ (OH)₂ (py)₂ ].

ABSTRACT: The photodecomposition mechanism of trans,trans,trans-[Pt(N₃ )₂ (OH)₂ (py)₂ ] (1, py=pyridine), an anticancer prodrug candidate, was probed using complementary Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), transient electronic absorption, and UV/Vis spectroscopy. Data fitting using Principal Component Analysis (PCA) and Multi-Curve Resolution Alternating Least Squares, suggests the formation of a trans-[Pt(N₃ )(py)₂ (OH/H₂ O)] intermediate and trans-[Pt(py)₂ (OH/H₂ O)₂ ] as the final product upon 420 nm irradiation of 1 in water. Rapid disappearance of the hydroxido ligand stretching vibration upon irradiation is correlated with a -10 cm^-1 shift to t

SUBMITTER: Vernooij RR 

PROVIDER: S-EPMC5947305 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature