Diffusion kurtosis imaging with free water elimination: A bayesian estimation approach.

ABSTRACT:

Purpose

Diffusion kurtosis imaging (DKI) is an advanced magnetic resonance imaging modality that is known to be sensitive to changes in the underlying microstructure of the brain. Image voxels in diffusion weighted images, however, are typically relatively large making them susceptible to partial volume effects, especially when part of the voxel contains cerebrospinal fluid. In this work, we introduce the "Diffusion Kurtosis Imaging with Free Water Elimination" (DKI-FWE) model that separates the signal contributions of free water and tissue, where the latter is modeled using DKI.

Theory and methods

A theoretical study of the DKI-FWE model, including an optimal experiment design and an evaluation of the relative goodness of fit, is carried out. To stabilize the ill-conditione

SUBMITTER: Collier Q 

PROVIDER: S-EPMC5947598 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature