Regenerative effects of human embryonic stem cell-derived neural crest cells for treatment of peripheral nerve injury.

ABSTRACT: Surgical intervention is the current gold standard treatment following peripheral nerve injury. However, this approach has limitations, and full recovery of both motor and sensory modalities often remains incomplete. The development of artificial nerve grafts that either complement or replace current surgical procedures is therefore of paramount importance. An essential component of artificial grafts is biodegradable conduits and transplanted cells that provide trophic support during the regenerative process. Neural crest cells are promising support cell candidates because they are the parent population to many peripheral nervous system lineages. In this study, neural crest cells were differentiated from human embryonic stem cells. The differentiated cells exhibited typical stellate morpho

SUBMITTER: Jones I 

PROVIDER: S-EPMC5947619 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature