Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies.

ABSTRACT: Colorectal cancer (CRC) biopsies underpin accurate diagnosis, but are also relevant for patient stratification in molecularly-guided clinical trials. The consensus molecular subtypes (CMSs) and colorectal cancer intrinsic subtypes (CRISs) transcriptional signatures have potential clinical utility for improving prognostic/predictive patient assignment. However, their ability to provide robust classification, particularly in pretreatment biopsies from multiple regions or at different time points, remains untested. In this study, we undertook a comprehensive assessment of the robustness of CRC transcriptional signatures, including CRIS and CMS, using a range of tumour sampling methodologies currently employed in clinical and translational research. These include analyses using (i) laser-captu

SUBMITTER: Alderdice M 

PROVIDER: S-EPMC5947827 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature