Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia.

ABSTRACT: The pathogenesis of preeclampsia (PreE), a hypertensive disorder of pregnancy, involves imbalanced T helper (T_H) cell populations and resultant changes in pro- and anti-inflammatory cytokine release. Elevated copeptin (an inert biomarker of arginine vasopressin (AVP)), secretion precedes the development of symptoms in PreE in humans, and infusion of AVP proximal to and throughout gestation is sufficient to initiate cardiovascular and renal phenotypes of PreE in wild-type C57BL/6J mice. We hypothesize that AVP infusion in wild-type mice is sufficient to induce the immune changes observed in human PreE. AVP infusion throughout gestation in mice resulted in increased pro-inflammatory interferon γ (IFNg) (T_H1) in the maternal plasma. The T_H17-associated cytokin

SUBMITTER: Scroggins SM 

PROVIDER: S-EPMC5947858 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature