Linking Alzheimer's disease and type 2 diabetes mellitus via aberrant insulin signaling and inflammation.

ABSTRACT: Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two progressive and devastating health disorders afflicting millions of people worldwide. The probability and incidence of both have increased considerably in recent years consequent to increased longevity and population growth. Progressively more links are being continuously found between inflammation and central nervous system disorders like AD, Parkinson's disease, Huntington's disease, motor neuron disease, multiple sclerosis, stroke, traumatic brain injury and even cancers of the nervous tissue. The depth of the relationship depends on the timing and extent of anti- or pro-inflammatory gene expression. Inflammation has also been implicated in T2DM. Misfolding and fibrillization (of tissue specific and/or non-specific pro

SUBMITTER: Kamal MA 

PROVIDER: S-EPMC5947865 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature