Inhibition of human monoamine oxidase A and B by flavonoids isolated from two Algerian medicinal plants.

ABSTRACT:

Background

Monoamine oxidases (MAOs) are outer mitochondrial membrane flavoenzymes. They catalyze the oxidative deamination of a variety of neurotransmitters. MAO-A and MAO-B may be considered as targets for inhibitors to treat neurodegenerative diseases and depression and for managing symptoms associated with Parkinson's and Alzheimer's diseases.

Purpose

The objective was to evaluate the inhibitory effect of Hypericum afrum and Cytisus villosus against MAO-A and B and to isolate the compounds responsible for the MAO-inhibitory activity.

Methods

The inhibitory effect of extracts and purified constituents of H. afrum and C. villosus were investigated in vitro using recombinant human MAO-A and B, and through bioassay-guided fractionation of ethyl acetate fractions of ar

SUBMITTER: Larit F 

PROVIDER: S-EPMC5947877 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature