Critical-depth Raman spectroscopy enables home-use non-invasive glucose monitoring.

ABSTRACT: One of the most ambitious endeavors in the field of diabetes technology is non-invasive glucose sensing. In the past decades, a number of different technologies have been assessed, but none of these have found its entry into general clinical use. We report on the development of a table-top confocal Raman spectrometer that was used in the home of patients with diabetes and operated for extended periods of time unsupervised and without recalibration. The system is based on measurement of glucose levels at a 'critical depth' in the skin, specifically in the interstitial fluid located below the stratum corneum but above the underlying adipose tissue layer. The region chosen for routine glucose measurements was the base of the thumb (the thenar). In a small clinical study, 35 patients with diab

SUBMITTER: Lundsgaard-Nielsen SM 

PROVIDER: S-EPMC5947912 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature