Dendritic Integration of Sensory Evidence in Perceptual Decision-Making.

ABSTRACT: Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβ_c KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (K_V4) in αβ_c KC dendrites. αβ_c KCs thus tailor

SUBMITTER: Groschner LN 

PROVIDER: S-EPMC5947940 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature