Differentiating between clinical and behavioral phenotypes in first-episode psychosis during maintenance of visuospatial working memory.

ABSTRACT:

Introduction

We probed the neural basis of working memory in individuals with first episode of psychosis (FEP) and assessed how these neural abnormalities are associated with behavioral performance and/or core to psychosis pathophysiology.

Methods

FEP (N=35) and matched controls (N=25) performed a visuospatial working memory task during fMRI acquisition. We isolated neural activity during the maintenance period and examined neural activity within regions typically engaged during a working memory task. Functional connectivity estimates were derived using psychophysiological interaction analysis. We examined correlations between brain function and behavioral performance and clinical symptomatology.

Results

FEP had reduced accuracy and slower reaction times compared to c

SUBMITTER: Jalbrzikowski M 

PROVIDER: S-EPMC5948111 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature